One AI backbone across both systems.

Kosa Whole-Brain Computing Engine

Built on multimodal signal sensing from fMRI, EEG and tFUS, the Kosa Whole-Brain Computing Engine closes the loop of sensing, computing, modulation and execution. It supports multimodal neuroimaging data integration and brain functional connectivity analysis, shifting target definition from population-based coordinates to individualized functional network computation.

Fully Automated Precision Execution

Achieves 0.9 mm targeting accuracy with sub-millimeter execution repeatability. Marker-free, non-contact 3D structured-light registration completed in 15 seconds ensures high consistency across treatment sessions, operators and study sites.

Simulation-Driven Individualized Planning

Using each patient's CT/MRI anatomical data, we perform electromagnetic field simulation and transcranial acoustic field correction. Going beyond conventional fixed-output paradigms, this enables highly precise, individualized neuromodulation planning and supports both ultrasound and electromagnetic stimulation modalities.

Closed-Loop Modulation and Monitoring

Compatible with EEG, eye-tracking, ECG and other biosignal acquisition systems, it supports flexible implementation of closed-loop feedback paradigms, synchronizing stimulation with brain state in real time.

Sunor-R Transcranial Focused Ultrasound Neuromodulation System (tFUS)

Sunor-R is a research-oriented tool for non-invasive deep brain neuromodulation. The field currently faces two major bottlenecks: first, accessing deep nuclei (e.g., via deep brain stimulation) is largely invasive; second, existing non-invasive ultrasound devices are mostly single- or dual-channel, lack transcranial aberration correction, and offer insufficient focusing accuracy to meet the demands of deep brain research. Centered on fully in-house developed phased-array technology and paired with transcranial correction algorithms, Sunor-R enables electronic and dynamic beam steering. It has passed type testing and animal studies, supporting a seamless transition from animal experiments to human research.

  • Research Flexibility — From cortex to deep nuclei, from a single nucleus to neural pathways. Whole-brain coverage with dynamically adjustable target number, size and position.
    - 64-element phased array — Independent channel control, supporting electronic and dynamic focusing.
    - Phased-array ultrasonic dynamic electronic focusing range — Axial ±30 cm, radial ±20 cm, covering deep brain nuclei.
    - Customizable transducers — 16–256 elements available, frequency range 200 kHz–2 MHz, adaptable to diverse experimental requirements.
  • Millimeter-Level Precision — Transcranial correction algorithms keep the focus from shifting or spreading
    - Focal spot size — 3 × 3 × 8 mm (at ~3 dB).
    - Transcranial correction algorithm — 97.5% correction accuracy against the accepted clinical standard, completed within minutes on a single consumer-grade GPU.
  • Stability and Reliability — Fully in-house developed and validated through type testing and animal studies
    - Fully in-house development — Proprietary phased-array transducers, multi-channel driving circuits and transcranial focusing algorithms, all under wholly independent IP; up to 1024-channel nanosecond-level synchronization (5 ns) guarantees consistency at the source.
    - Safety validation — Ultrasound is non-invasive, reversible and non-destructive; safety has been verified through type testing, animal studies and skull experiments.
    - Platform services — Beyond 64-channel-and-above precision targeting hardware, we offer animal study services, protocol design support and a target and functional connectivity data analysis platform, all connected to a global network of collaborating researchers.
  • Product Matrix
    64-CH animal research system (delivered to leading research institutions in China and abroad) / 64-CH clinical research system (with navigated robotic arm; type testing imminent) / 1024-CH medical system (in development; 1024-channel nanosecond-level synchronization).
    Application Scenarios
    1. Small animals — Rats, mice
    2. Large animals — Dogs, rabbits, pigs, non-human primates
    3. Human research settings — Seamless transition from animal studies to human research
    Core Application Areas
    1. Deep brain nucleus modulation: thalamus, hippocampus, amygdala, basal ganglia and others
    2. Indication research: major depressive disorder, Alzheimer's disease, Parkinson's disease, epilepsy, disorders of consciousness, substance addiction, sleep disorders and others

If you are interested in applying this transcranial focused ultrasound system in neuroscience research, please contact us. We will walk you through the core technology, tailor a solution to your direction — preclinical research, human studies, brain-region-specific investigations and more — and share real-world use cases from partner laboratories.

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Neuronavigated Transcranial Magnetic Stimulation System (TMS)

Addressing the limitations of conventional treatment — dependence on clinician experience, complex workflows and slow onset — KongshanCi has developed a fully automated closed-loop neuromodulation system. It integrates individualized target computation, electric field simulation, 3D structured-light registration, robotic-arm automated threshold assessment and precision execution, enabling fully automated target selection, positioning, alignment, dosing and delivery. Safe, non-invasive, and delivered in a rapid 5-day course, this approach offers a standardized, automated therapy for patients with major depressive disorder.

  • Individualized — Targets computed accurately, electric fields made visible
    Based on resting-state fMRI, individualized functional-connectivity targets are computed fully automatically, moving treatment from empirical judgment to precision computation. rs-fMRI functional-connectivity-weighted targeting replaces the visual 5 cm rule, with repeat-placement error ≤ 2 mm. Individualized electric field simulation achieves ≥ 97.5% accuracy, enabling highly focused mapping between intracranial targets and scalp stimulation pose. Three invention patents correspond precisely to the three core technologies: target computation, electric field simulation and spatial registration.
  • Fully Automated — Operated by a single clinician, no cumbersome manual steps
    Marker-free 3D structured-light registration completes automatically in 15 seconds with ≤ 0.5 mm error. Robotic-arm-guided automated threshold assessment converges in ≤ 5 minutes (versus roughly 10 minutes manually), with repeat-measurement error of only 3.73%. Sub-millimeter automated execution achieves 0.9 mm accuracy and is fully traceable throughout.
  • Clinically Effective — Rapid onset within 5 days, safe and non-invasive
    A GCP clinical trial was initiated synchronously across 15 hospitals, including four National Medical Centers for Mental Disorders in China.Daily pulse counts are only 50% of those used in leading international therapies, with a total of 45,000 pulses — lower dose, higher efficiency and greater benefit.

If you would like to apply this TMS system in your research or clinical program, please contact us for further details.

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